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1
2019 - 08 - 16
随全球医药外包转移及国内外包需求释放,我国医药外包未来成长空间较大,行业呈现“一超多强、两极分化”格局,CMO成长迅速且以化学药为主,国内具备国际资质认证的CRO企业是国内外药企进行药品全球化布局的首要选择。一、我国医药外包行业发展历程我国外包服务行业与全球有着相似的发展轨迹,受政策环境与行业环境发展影响,也经历了萌芽、发展、成熟、整合等阶段。表1 我国CRO行业发展历程资料来源:公开资料整理二、国内医药外包行业发展现状国内CMO主要受国际业务带动,随MAH实施、小型创新企业发展及生物药兴起,国内企业外包生产服务规模不断扩大。2001年中国正式成为世贸组织成员,对药品知识产权的保护吸引了辉瑞、赛诺菲、礼来等一批国际制剂企业的进驻。由此带动中国CMO市场的兴起。近年来,随着国家鼓励创新政策及MAH制度的实施,小型创新企业发展,我国CMO的下游客户逐渐扩大至本土企业。但由于我国创新自主研发终端市场仍未放开,国内企业业务发展仍较为缓慢。不过,近年来随我国生物药的不断突破,生物药产业化进程加快,由于生物药生产制造的复杂性,国内相关生物药CMO服务蓬勃兴起。1. 我国医药研发成本较发达国家具有非常大的竞争优势与欧美等发达国家相比,我国医药外包行业相对起步较晚,20多年前才由跨国药企在中国播下医药外包产业的种子。但我国拥有庞大的患者和丰富的疾病谱,在临床试验方面拥有得天独厚的资源。同时我国医药...
2
2019 - 05 - 23
2019年5月22日 讯 /生物谷BIOON/ --早稻田大学Toshio Ohshima教授的一项新研究发现,抑制塌陷反应介质蛋白2(CRMP2)(一种微管结合蛋白)的磷酸化可以抑制神经纤维的退化,促进视神经损伤后的再生。最近在《Scientific Reports》杂志上发表的这项研究结果可以为视神经病变患者开发新型治疗方法。青光眼患者视野中会出现盲点,并且当视神经恶化时可能导致失明。神经纤维的这种恶化和功能丧失也发生在创伤性神经损伤和神经系统疾病,例如阿尔茨海默病和ALS中。目前,由于轴突再生受到抑制因子的限制,因此不存在在损伤或变性后完全修复视网膜,脊髓和中枢神经系统的其他部分的方法。(图片来源:Www.pixabay.com)在过去的研究中,已经发现了抑制轴突再生的潜在机制,并且认为解决这些机制可以使科学家们在开发新的中枢神经系统损伤治疗方法方面更进一步。CRMP2蛋白质分子起到稳定微管的作用,微管在神经元细胞水平为中枢神经系统提供结构支持,并通过与微管蛋白二聚体结合促进聚合。然而,这些功能通过磷酸化(一种调节神经元蛋白的机制)被各种激酶阻止。“在我们之前的研究中,我们所做的是开发CRMP2敲入小鼠并从基因上抑制其CRMP2磷酸化,”Ohshima教授解释说。 “结果,CRMP2敲入小鼠在脊髓损伤后表现出轴突再生的促进。由此,我们假设在视神经损伤后也可以观察到相同的现象。...
3
2019 - 05 - 13
2019年5月23日讯 /生物谷BIOON /——发表在《JNeurosci》上的一项研究发现,缺乏Shank3基因的老鼠在前额皮质显示出结构和功能缺陷。这项研究增进了我们对自闭症谱系障碍最常见的遗传风险因素之一的理解。Shank3突变在患有自闭症和相关发育障碍的人群中很常见。先前的动物研究表明,Shank3和基底神经节功能障碍之间存在关联,这可能导致自闭症的重复性行为特征。在人类中,Shank3突变也与智力和语言障碍有关。图片来源: JNeurosciMarco Pagani、Alessandro Gozzi和他们的同事在成年雄性小鼠身上使用磁共振成像技术,发现缺乏Shank3的动物的前额皮质连接性和灰质体积减少。研究人员报告说,这些大脑差异与雌鼠的社交活动受损密切相关。这些发现证实了Shank3在维持前额皮质连接方面的作用,这可能会增加自闭症风险。(生物谷Bioon.com)参考资料:Alessandro Gozzi eT al. DeleTion of AuTism Risk Gene Shank3 DisrupTs PrefronTal ConnecTiviTy, JNeurosci (2019). DOI: 10.1523/JNEUROSCI.2529-18.2019
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产品名称: K3 Plus酶标仪
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时间: 2019 - 05 - 23
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时间: 2019 - 04 - 22
描述The LIVE/DEAD™ Fixable Green Dead Cell Stain Kit is used to determine the viability of cells prior to the fixation and permeabilization required for intracellular antibody staining or prior to elimination of biohazardous materials using formaldehyde fixation. This kit has been optimized and validated for use with a blue laser flow cytometer.• Stable—dyes are freeze dried in separate vials to maintain stability• Robust—staining pattern is the same before and after fixation• Bright signal—allows...
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时间: 2019 - 04 - 18
描述This product detects the externalization of phosphatidylserine in apoptotic cells using recombinant annexin V conjugated to green-fluorescent FITC dye and dead cells using propidium iodide (PI). Propidium iodide stains necrotic cells with red fluorescence. After treatment with both probes, apoptotic cells show green fluorescence, dead cells show red and green fluorescence, and live cells show little or no fluorescence.
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时间: 2019 - 04 - 18
描述SYTOX® Green nucleic acid stain is an excellent green-fluorescent nuclear and chromosome counterstain that is impermeant to live cells, making it a useful indicator of dead cells within a population.•  Impermeant to live cells•  Excitation/Emission: 504/523 nm•  Use with 488 Argon-ion laser•  Works with mammalian cells and both Gram-positive and Gram-negative bacteriaSimple Viability Determination SYTOX® Green allows quick determination of cell viability when usin...
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时间: 2019 - 04 - 18
描述Premo™ FUCCI Cell Cycle Sensor is a fluorescent, two-color sensor of cell cycle progression and division in live cells. It allows accurate and sensitive cell cycle analysis of individual cells or a population of cells by fluorescence microscopy, flow cytometry, or high-content imaging.At 2 x 200 µL, this is a smaller pack size version (1/5 volume) of the popular full-size product and perfect for testing its performance in your system.The Premo™ FUCCI Cell Cycle Sensor is delivered by high...
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时间: 2019 - 04 - 18
描述CountBright™ absolute counting beads are a calibrated suspension of microspheres that are brightly fluorescent across a wide range of excitation and emission wavelengths (UV to 635 nm excitation and 385-800 nm emission). CountBright™ absolute counting beads are mixed with the cell sample and assayed via flow cytometry. By comparing the ratio of bead events to cell events, absolute numbers of cells in the sample can be calculated. Because CountBright™ beads are mixed in the test sample, absolut...
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时间: 2019 - 04 - 17
描述CellTrace™ CFSE Cell Proliferation Kit is used for in vitro and in vivo labeling of cells to trace multiple generations using dye dilution by flow cytometry.• Superior performance—bright, single-peak staining enables visualization of multiple generations• Long-term signal stability—well-retained in cells for several days post stain• Non-toxic—staining does not adversely effect cell health• Simple, robust staining protocolView a selection guide for all CellTrace™ Cell Proliferation Kits fo...
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时间: 2019 - 04 - 17
描述CellTrace™ CFSE 细胞增殖试剂盒 (CellTrace™ CFSE Cell Proliferation Kit) 以方便的一次性瓶装形式提供用途广泛,稳定性高的细胞示踪剂。 羧基荧光素二醋酸盐琥珀酰亚胺酯,常称为 CFSE,可被动扩散进入细胞。 这种试剂没有颜色和荧光,直至细胞内的酯酶去除其醋酸盐基团,产生能发出明亮荧光的羧基荧光素琥珀酰亚胺酯。 琥珀酰亚胺酯与细胞内氨基反应,形成稳定且能用醛固定剂固定的荧光偶联物。 此试剂盒包含十份一次性瓶装的 CFSE,因此进行小规模实验时无需制备过量的易变质 CFSE 储存液。 此试剂盒还包括高质量的 DMSO(二甲基亚砜)和详细的实验方案。For Research Use Only. Not for use in diagnostic procedures.图表Suppressive capacity of isolated Treg cells.Suppressive capacity of isolated Treg cells. (A) CD4+ CD25–cells were stained with Ca...
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时间: 2019 - 04 - 17
描述The Click-iT® EdU Pacific Blue™ Flow Cytometry Assay Kit provides a simplified, more robust assay for analyzing DNA replication in proliferating cells as compared to traditional BrdU methods. Newly synthesized DNA is analyzed using the 405 nm laser of the flow cytometer.• Accurate—superior results compared to BrdU assays• Fast—results in as little as 90 minutes• Economical—more assays per kitView selection guide for all Click-iT™ EdU and Click-iT™ Plus EdU assays for flow c...
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时间: 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.• Free Attune NxT software with researcher-inspired upgrades• New green laser option for expanded utility and fluorochrome options• Simple push...
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时间: 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.• Free Attune NxT software with researcher-inspired upgrades• New green laser option for expanded utility and fluorochrome options• Simple push...
型号:
时间: 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.• Free Attune NxT software with researcher-inspired upgrades• New green laser option for expanded utility and fluorochrome options• Simple push...
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